Pathological analysis of development of intraductal papillary neoplasm of bile duct

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19068
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Shizuoka Cancer Center Research Institute
• Principal Investigator: Kakuda Yuko 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (90748435)
• Research Collaborator: NAKANUMA yasuni ; FUKUMURA yuki ; TAKASE masaru ; SERIZAWA masakuni ; SUGINO takashi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 胆管内乳頭状腫瘍 / 胆道癌

Outline of Final Research Achievements

Intraductal papillary neoplasm of bile duct (IPNB) is precursor lesion of invasive adenocarcinoma of bile duct. IPNBs are reported to be subdivided into 4 histologic subtypes (intestinal, gastric, oncocytic, pancreato-biliary), and to be heterogeneous with respect to their anatomical site along the biliary tree. In this study, IPNBs can be divided subgroup with respect to histologic similarities to intraductal papillary mucinous neoplasm of pancreas. By gene mutation analysis, some gene mutation showed association with histologic subtypes, subgroups, tumor location, and macroscopic mucin secretion. To investigate mechanisms of tumorigenesis and progression of IPNB, subtypes and other factors related to IPNB should be considered in future.

Free Research Field

病理学