2017 Fiscal Year Final Research Report
Why does atopic dermatitis often relapse in the same skin region?
| Project/Area Number |
15K19076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アトピー性皮膚炎 / 接触性皮膚炎 / 組織常在性記憶T細胞 / 皮膚局所の免疫記憶 |
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| Outline of Final Research Achievements |
The reason why atopic dermatitis often relapses in the same skin region is unclear. By using a mouse model, we found that the skin that had experienced inflammation and cured showed an accelerated inflammatory response upon reexposure to the same antigen. This 'local skin memory (LSM)' response involved tissue resident memory T cells (TRM cells) that remained in the inflammation-experienced skin for a long time. Analyses of the antigen-reexposed skin showed that the initiation of the LSM response involved inflammatory cytokines including interferon γ secreated from the activated TRM cells. Thus, these results suggest that the removal of TRM cells from the inflammation-experienced skin region will be needed to prevent the relapsing of atopic dermatitis.
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| Free Research Field |
免疫学
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