2017 Fiscal Year Final Research Report
Structural Analysis of Non Mevalonate Pathway Enzyme Groups aiming at Development of Novel Antimalarial Drugs
| Project/Area Number |
15K19086
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Parasitology (including sanitary zoology)
|
|---|
| Research Institution | Yokohama College of Pharmacy |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | マラリア / 非メバロン酸経路 / X線結晶構造解析 |
|---|
| Outline of Final Research Achievements |
To lead to the development of novel antimalarial drugs, we aimed to clarify the three-dimensional structure of the non-mevalonate pathway group derived from Plasmodium falciparum, establishing the expression of the target protein, examining the purification conditions, and conducting a crystallization experiment.
Although it could not clarify the structure, we succeeded in large-scale purification for several target proteins and screened for crystallization conditions.
|
| Free Research Field |
構造生物学
|
