2016 Fiscal Year Final Research Report
Analysis of the role for human herpesvirus 6 gM/gN entry
| Project/Area Number |
15K19112
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
Mori Yasuko 神戸大学, 大学院医学研究科・臨床ウイルス学分野, 教授
Serada Satoshi 国立研究開発法人 医薬基盤, 健康・栄養研究所, 免疫シグナルプロジェクト
Naka Tetsuji 国立研究開発法人 医薬基盤, 健康・栄養研究所, 免疫シグナルプロジェクト
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ウイルス / 細胞 / 宿主因子 |
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| Outline of Final Research Achievements |
Human herpesvirus-6 (HHV-6) causes exanthem subitum and sometimes develops sever encephalitis. But the infection mechanism of HHV-6 is unknown. Recently, we analyzed the viral glycoprotein complex glycoprotein M (gM)/gN on HHV-6 envelope. gM/gN complex interacted with a cellular factor was incorporated into virions. Tegument constituted by tegument proteins is the component of viral particles. These proteins interacted with the envelope glycoproteins play an important role for the formation of virions.
We analyzed about the HHV-6 tegument protein U14. U14 has the multiple role for HHV-6 infection and interacted with several proteins. In this study, we isolated the new cellular factor associated with U14. We revealed that this protein was important for HHV-6 infection.
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| Free Research Field |
ウイルス学
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