2017 Fiscal Year Final Research Report
Function of Japanese encephalitis genome circularization on viral replication
| Project/Area Number |
15K19115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 日本脳炎ウイルス / ゲノム環状化 / 相補性 / 複製 |
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| Outline of Final Research Achievements |
Functional analyzes of four pairs of complement sequences found in Japanese encephalitis virus (JEV) genome terminus were conducted to elucidate the effect of the genome circularization on virus replication. As results, essential sequences and/or complementarity for genome circularization as well as virus replication were determined. These regions possessed identical functions both in mammalian cells and mosquito cells. The essential sequences and/or complementarity for genome circularization were all important for virus replication. On the other hand, the essential sequences and/or complementarity for virus replication were not always essential for genome circularization. Since functions of these regions of JEV genome have been largely unknown, findings obtained in the present study can contribute to the novel anti JEV drug development which has not been available yet.
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| Free Research Field |
ウイルス学、ワクチン学
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