Regulation of HBs antigen expression in HBV genotype A infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: YAMAMOTO Naoki 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 (10547780)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ウイルス抗原発現制御

Outline of Final Research Achievements

Hepatitis B virus (HBV) antigens are involved in the suppression of the immune response to the virus. HBs antigens in cells infected with genotype A (Gt-A) virus were more abundantly expressed than those in cells infected with genotype C (Gt-C) virus. In the present study, transcription and translation efficiency were examined to analyze the regulatory mechanisms of HBs antigen expression. The results revealed that the transcription activities of the S1 and S2 promoters derived from Gt-A and Gt-C are comparable. In addition, no significant difference was observed in translation efficiency. These results suggest that HBs antigen expression is regulated after translation.

Free Research Field

ウイルス学