2017 Fiscal Year Final Research Report
Analysis on the mechanism of immune regulation by plasmacytoid dendritic cells in the development of autoimmune diseases
| Project/Area Number |
15K19134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 形質細胞様樹状細胞 / I型インターフェロン / 自己免疫疾患 / 炎症反応 / Toll様受容体 |
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| Outline of Final Research Achievements |
Plasmacytoid dendritic cells (pDCs) are important for the innate and adaptive immune responses by producing robust type-I interferon (IFN-I) through the toll-like receptor (TLR)-mediated signaling. However, how pDCs control TLR-mediated immune responses that cause autoimmunity remains unclear. In this study, we demonstrated a critical function of pDCs in the induction of TLR7-mediated innate and adaptive immune responses that cause autoimmunity using gene-modified mice with impaired expression of Siglec-H and selective ablation of pDCs. Our findings reveal that pDCs provide an essential link between TLR7-mediated innate and adaptive immunity for the initiation of IFN-I-associated autoimmune inflammation.
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| Free Research Field |
免疫学
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