Role of CD28 co-stimulation in homeostasis of peripherally-derived regulatory T cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19137
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Tokyo University of Science
• Principal Investigator: Wakamatsu Ei 東京理科大学, 研究推進機構生命医科学研究所, 助教 (40632617)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 制御性T細胞 / CD28 / 末梢由来制御性T細胞 / 分化 / 増殖

Outline of Final Research Achievements

Regulatory T cells (Tregs) are classified into thymus-derived Tregs and peripherally-derived Tregs (pTreg). It has not been fully understood how CD28 influences on homeostasis of pTreg. Thus, we attempted to investigate the role of CD28 in homeostasis of pTreg. We found that pTreg was significantly reduced in secondary lymphoid organs (SLOs) of CD28 knockout mice. And we clarified that the reduction of pTreg in SLOs of CD28 KO mice was due to the impairment of proliferation. Our study indicate that CD28 regulates proliferation of pTreg, leading to the maintenance of homeostasis of pTreg.

Free Research Field

免疫学