2017 Fiscal Year Final Research Report
The effect of gastrointestinal damage on drug absorption
| Project/Area Number |
15K19166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
OHTANI Hisakazu
IMAOKA Ayuko
TSUJII Kazunari
WADA Naoki
YOTSUMOTO Keiichi
HATTORI Tomoki
TSUCHITANI Toshiaki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 消化管障害 / 抗がん剤 / トランスポーター / バイオアベイラビリティ / ダビガトラン |
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| Outline of Final Research Achievements |
5‐Fluorouracil (5‐FU) and Irinotecan, an anticancer drug, causes severe gastrointestinal damage, which may affect the absorption of orally administered drugs including the ubstrates of intestinal uptake and efflux transporters. This study aimed to investigate quantitatively the effect of 5‐FU or Irinotecan‐induced intestinal damage on the PK/PD of Dabigatran using rat model. The 5‐FU and Irinotecan‐induced intestinal damage may affect transporter‐mediated drug absorption of orally administered drugs in the clinical setting.
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| Free Research Field |
臨床薬物動態学
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