2016 Fiscal Year Final Research Report
Construction of cancer chronotherapy by manipulation of biological clock via mTOR signal pathway.
| Project/Area Number |
15K19167
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | mTOR / がん / 時計遺伝子 / 体内時計 |
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| Outline of Final Research Achievements |
To elucidate the interaction between the diurnal rhythm of mTOR signal and the circadian clock system, and to find a new therapeutic strategy for cancer and other mTOR related diseases by manipulating mTOR diurnal rhythm, this research was carried out. Two reports on cancer proliferation and biological clock mechanism were published. I also clarified a part of the interaction of the effect of the diurnal rhythm of the mTOR signal and its inhibition on the internal clock mechanism. These findings will find the possibility of application as a new target on the influence of mTOR signal in elucidation and treatment of various diseases such as cancer.
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| Free Research Field |
腫瘍治療学
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