2016 Fiscal Year Final Research Report
Study for mechanisms of drug-induced severe cutaneous reactions
| Project/Area Number |
15K19168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Okamoto-Uchida Yoshimi (内田) 国立医薬品食品衛生研究所, 医薬安全科学部, 任期付研究員 (40716792)
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| Research Collaborator |
Kanoh Naoki 東北大学, 東北大学大学院薬学研究科, 准教授
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| Project Period (FY) |
2015-03-01 – 2017-03-31
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| Keywords | スティーブンス・ジョンソン症候群 / 中毒性表皮壊死症 / HLA / 医薬品 / 分子間相互作用 |
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| Outline of Final Research Achievements |
Recent studies have revealed that the prevalence of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis (SJS/TEN) is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, molecular mechanism involved in the SJS/TEN onset has been largely unknown. In this project, we developed a system for determination of affinity between drug and HLA protein. This system would be useful for estimation of drug adverse reactions.
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| Free Research Field |
医療系薬学
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