2016 Fiscal Year Final Research Report
The significance of autotaxin as a tumor marker in hematological malignancies
| Project/Area Number |
15K19173
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Masuda Akiko 東京大学, 医学部附属病院, 助教 (70572717)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | オートタキシン / リゾホスファチジン酸 |
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| Outline of Final Research Achievements |
Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. We previously reported the clinical significance of serum ATX measurements. The serum ATX antigen levels in patients with B-cell neoplasms, especially with follicular lymphoma (FL), were higher than those in healthy subjects.
In the present study, we examined the surface expression of ATX in peripheral blood cells from healthy subjects and patients with hematological malignancies. Although we measured the expression of ATX using several antibodies, the expressions of ATX were vaiable.
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| Free Research Field |
病態検査学
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