Investigation erythrocyte-associated cholesterol metabolism and its disorder.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ohkawa Ryunosuke 東京医科歯科大学, 大学院保健衛生学研究科, 助教 (50420203)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 赤血球 / コレステロール / 高比重リポタンパク / 低比重リポタンパク / 血清アミロイドA

Outline of Final Research Achievements

Since erythrocyte contains cholesterol abundantly at the same degree as that in plasma, it is speculated that the erythrocyte is associated with cholesterol metabolism but the mechanism has not been fully elucidated. Hence, we investigated the erythrocyte-related cholesterol metabolism and its disorder. Our results demonstrated that the erythrocyte was involved in cholesterol acceptance and delivery with high-density lipoprotein (HDL) and low-density lipoprotein, and played a role in reverse cholesterol transport pathway as a cholesterol pool. In addition, we successfully produced and characterized one of dysfunctional HDL (dys-HDL), serum amyloid A-contained HDL, which is produced from liver during inflammation, in order to investigate an association between erythrocyte-related cholesterol metabolism and dys-HDL.

Free Research Field

病態検査学