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2017 Fiscal Year Final Research Report

The role for Mediator subunits MED1 in the property of breast carcinomas

Research Project

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Project/Area Number 15K19180
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionKobe University

Principal Investigator

Hasegawa Natsumi  神戸大学, 保健学研究科, 助教 (20708599)

Co-Investigator(Renkei-kenkyūsha) ITO Mitsuhiro  神戸大学, 保健学研究科, 教授 (50362794)
Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsMED1 / 乳癌 / 発癌
Outline of Final Research Achievements

We previously reported that Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. In order to determine the role for MED1 in the property of breast carcinomas, prognosis, and response to therapy, we have prepared, or are in the process of preparing, mice carrying various mutations in MED1 and MED1-associated factor. We have analysed these mutant mice that have been ready so far if these mice possess the ability of inhibiting breast cancer.

Free Research Field

腫瘍検査学

URL: 

Published: 2019-03-29  

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