Identification of novel effluent biomarkers for peritoneal deterioration in peritoneal dialysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19187
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Juntendo University
• Principal Investigator: Idei Mayumi 順天堂大学, 医学部, 非常勤助教 (40596623)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 慢性腎臓病 / 腹膜障害 / 腹膜透析 / 腹膜劣化 / ERC/mesothelin

Outline of Final Research Achievements

The peritoneal deterioration is associated with encapsulating peritoneal sclerosis which is the most serious complication of peritoneal dialysis. We identified novel biomarkers in peritoneal effluent to predict peritoneal deterioration in peritoneal dialysis. ERC/mesothelin is expressed in normal mesothelial cells, and is cleaved by a furin-like protease into two fragments: secreted N-ERC/mesothelin and membrane-bound C-ERC/mesothelin. We examined whether ERC/mesothelin predicts peritoneal deterioration. There were significant correlation between peritoneal function (D/P Cr) and N-ERC/mesothelin in peritoneal effluent. In multivariate analysis, N-ERC/mesothelin in peritoneal effluent was identified as an independent predictor of peritoneal deterioration even after adjusting for age, duration of peritoneal dialysis, and glomerular filtration rate. We concluded that N-ERC/mesothelin in peritoneal effluent predicts peritoneal deterioration.

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