Genome-Metabolome Association Study for Hyperuricemia

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19231
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Keio University
• Principal Investigator: Harada Sei 慶應義塾大学, 医学部(信濃町), 助教 (10738090)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: メタボローム / 疫学 / 遺伝子多型 / 個別化医療 / 予防医学 / 高尿酸血症 / ABCG2 / コホート研究

Outline of Final Research Achievements

The genome-metabolome association study for hyperuricemia was conducted in the large scale metabolomics cohort study in Tsuruoka City, Japan. It was clarified that most of plasma metabolites were associated with the level of serum uric acid in this first study among Japanese. It was also shown that ABCG2 polymorphism was associated with the level of serum uric acid, as well as concentrations of plasma metabolites. The relation between hyperuricemia and plasma metabolomic profile was partly affected by ABCG2 polymorphism. In particular, the relation between hyperuricemia and N,N-dimethylglycine was different by ABCG2 polymorphism in both of male and female. These findings suggest that further researches may proceed the tailor-made preventive medicine using genome and metabolome for hyperuricemia.

Free Research Field

メタボロミクス疫学