2017 Fiscal Year Final Research Report
Elucidation of adiponectin expression pathway based on the co-expression network and epigenome data analysis
| Project/Area Number |
15K19242
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hygiene and public health
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
YOKOTA Mitsuhiro 愛知学院大学, 歯学部, 教授 (50201851)
MATSUBARA Tatsuaki 愛知学院大学, 歯学部, 教授 (30209598)
ICHIHARA Sahoko 自治医科大学, 医学部, 教授 (20378326)
YAMAMOTO Ken 久留米大学, 医学部, 教授 (60274528)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | エピゲノム / レジスチン / アディポネクチン / バイオインフォマティクス / DNAメチル化 / SNP / 生活習慣病 / 心筋梗塞 |
|---|
| Outline of Final Research Achievements |
Abnormal secretion of adiponectin is deeply involved in the development of lifestyle disease. The blood concentration is known to be affected by the genetic factors. However, the variance of the concentration explained by genes previously identified as associated genes with concentrations is very low.
In this study, we explored DNA methylation sites associated with the adiponectin based on a gene co-expression network analysis and an integration analysis with DNA methylation level using the data for 191 nondiabetic men from a general population and public available data sets. As a result, we identified three sites for both adiponectin level and the expression level of ADIPOQ gene. One site of them was located near a gene, which regulate of ADIPOQ. These results suggest new insights into the regulation of adiponectin via effects on epigenetics.
|
| Free Research Field |
バイオインフォマティクス
|
