2016 Fiscal Year Final Research Report
Carcinogenicity and species differences by indium compounds exposure.
| Project/Area Number |
15K19252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | インジウム |
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| Outline of Final Research Achievements |
The aim of this study was to assess the mechanism of carcinogenesis and those species differences of indium tin oxide (ITO). ITO, indium oxide and indium hydroxide was exposed to mouse, rat and human macrophage cell lines, respectively. Rat cell lines with highest phagocytic ability in these cell lines were most susceptible to cytotoxicity tests. This observation suggest that phagocytosis was involved in the development of cytotoxicity of indium compounds. Further, exposure to indium oxide induced high levels of reactive oxygen species generation and DNA damage in comparison to ITO and indium hydroxide. It is need to further studies the toxicity of indium oxide in addition to ITO.
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| Free Research Field |
産業衛生学
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