2017 Fiscal Year Final Research Report

Fatty acid intake for prevention of dementia -Focused on insulin resistance and inflammation-

Research Project

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Project/Area Number	15K19253
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene and public health
Research Institution	National Center for Geriatrics and Gerontology
Principal Investigator	OTSUKA Rei 国立研究開発法人国立長寿医療研究センター, NILS-LSA活用研究室, 室長 (00532243)
Research Collaborator	NISHITA Yukiko 国立長寿医療研究センター, 老年学・社会科学研究センター・NILS-LSA活用研究室, 研究員 (60393170) TANGE Chikako 国立長寿医療研究センター, 老年学・社会科学研究センター・NILS-LSA活用研究室, 研究員 (40422828) TOMIDA Makiko 国立長寿医療研究センター, 老年学・社会科学研究センター・NILS-LSA活用研究室, 研究員 (40587565) NAKAMOTO Mariko 徳島大学, 大学院・医歯薬学研究部・栄養科学部門, 助教 (40722533) KATO Yuki 愛知淑徳大学, 健康医療科学部, 教授 (20329650) ANDO Fujiko 愛知淑徳大学, 健康医療科学部, 教授 (90333393) SHIMOKATA Hiroshi 名古屋学芸大学, 大学院・栄養科学研究科, 教授 (10226269)
Project Period (FY)	2015-04-01 – 2018-03-31
Keywords	脂肪酸 / 認知機能 / 縦断研究 / インスリン抵抗性
Outline of Final Research Achievements	The present study aimed to clarify the effects of fatty acid intake on a cognitive decline which is exacerbated by insulin resistance and inflammation from a longitudinal study (NILS - LSA) among community dwellers. As a result, (1) the level of glucose metabolism strongly correlated with the decline in intelligence/cognitive function rather than the inflammatory state, (2) fatty acid intake and blood fatty acid concentration did not inhibit the cognitive decline exacerbated by insulin resistance and inflammation,(3) the association between glucose metabolism and cognitive function was strongly influenced by lifestyles, such as physical activities, smoking habit and high blood pressure, rather than fatty acid. These results indicate that fatty acid intake is not inhibitive for cognitive decline exacerbated by insulin resistance and inflammation, while adequate nutrition (fatty acid intake) to control sugar metabolism and obesity is effective for dementia prevention.
Free Research Field	疫学