Acute kidney injury with lipid peroxidation using the rodent models in rhabdomyolysis caused by heatstroke

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19270
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Legal medicine
• Research Institution: Tohoku Medical and Pharmaceutical University (2016); Chiba University (2015)
• Principal Investigator: NARA Akina 東北医科薬科大学, 医学部, 助教 (50722576)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 横紋筋融解症 / 腎機能障害 / グリセロール / 脂質過酸化 / 炎症性サイトカイン

Outline of Final Research Achievements

This study investigated the short-term effects of both lipid peroxidation and inflammatory responses on rhabdomyolysis-induced acute kidney injury (AKI). Rhabdomyolysis was induced by glycerol in saline into the rats. Time-dependent increases in serum biochemical parameters were observed 1 hour after glycerol injection. In kidneys, glycerol injection resulted in histopathological changes. We found an increases in lipid peroxidation-mediated oxidative and nitrosative stress within a few hours after glycerol injection and a release of pro-inflammatory cytokines.
Our findings suggest that pro-inflammatory cytokine-mediated inflammatory response might lead to rhabdomyolysis-induced AKI during the very first few hours after glycerol injection, and lipid peroxidation-mediated oxidant injury could promote the development of associated pathophysiological processes.

Free Research Field

法医学