2017 Fiscal Year Final Research Report
Evaluation of oxidative stress and elucidation of pathogenesis in Alzheimer disease by in vivo electron paramagnetic resonance imaging
| Project/Area Number |
15K19288
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Research Collaborator |
FUJII Hirotada
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | アルツハイマー病 / アミロイドβ / トランスジェニック / 酸化ストレス |
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| Outline of Final Research Achievements |
The purpose of this study is to analyze the mechanism of Alzheimer disease (AD) and apply the result to new therapeutic strategy, by evaluating the change of oxidative stress, cognitive function and histopathology in the brain when therapeutic intervention was given to AD model animals. I used in vivo electron paramagnetic resonance (EPR) imaging in order to evaluate the oxidative stress in the brain of model animals. APPswe/PS1dE9 mice (AD mice) and their littermates (Wild mice) were orally dispensed 5mg/kg of galantamine or distilled water from very early stage (3 months of age) or from early stage (6 months of age) of AD.
The results of behavioral assessment by novel object recognition (NOR) test indicated the improvement in congnitive function. Aβ deposition in the cortex decreased in the galantamine-administered group compared with control group. EPR imaging tend to visualize the less oxidative stress in the galantamine treatment group.
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| Free Research Field |
神経内科
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