Improvement of liver stiffness measured using magnetic resonance elastography after DAAs-based therapy in patients with chronic hepatitis C

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19290
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yokohama City University
• Principal Investigator: Tomeno Wataru 横浜市立大学, 附属病院, 助教 (00644957)
• Research Collaborator: SAITO Satoru
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: C型慢性肝炎 / 肝硬度 / MRエラストグラフィ / SVR後発癌

Outline of Final Research Achievements

We assessed liver stiffness (LS) using magnetic resonance elastography before and after direct acting antivirals (DAAs)-based therapy in 52 patients with chronic hepatitis C. The median LS measurement (LSM) significantly decreased at end of treatment (3.01 kPa) and 6 months after end of treatment (2.59 kPa) compared with baseline (3.69 kPa)(p<0.001). However, we discovered some cases that the LSM turned worse. In the future, a large-scale and long-term analysis of patients with smaller improvements in LSM could enable patients with a high risk of carcinogenesis after HCV elimination to be identified.

Free Research Field

ウイルス性肝炎