2017 Fiscal Year Final Research Report
Analysis of the mechanism of herbal medicines and identification of ingredients derived from herbal medicines for organ transplant rejection
| Project/Area Number |
15K19296
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 移植免疫 / 漢方薬 / 漢方生薬 / マウス / 心臓移植 / 生着延長 / 制御性T細胞 |
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| Outline of Final Research Achievements |
We investigated the effects on the graft survival of 148 kinds of Japanese herbal medicines recognized officially by Japanese government in the murine cardiac transplant model. In 2016 to 2017, almost all of herbal medicines were completed. Of 148, Shigyaku-san (TJ-35), Shohangekabukuryo-to (TJ-21), and Rikkunshi-to (TJ-43) were furthermore investigated. Our models given TJ-35 and TJ-21 had the significant prolongation of graft survival and could induce the generation of regulatory T cells. In the next study on the mechanisms of each medicine, our models given Kanzo and the main ingredient, Glycyrrhizic acid, could prolong the allograft survivals. In the study of TJ-43, we showed a mild survival prolongation by the administration after grafting and also the improvement of reduction of food intake, suggesting that TJ-43 had the evidence on the treatment of appetite loss after intestinal ileus. This study was published in Transplant International and Transplantation Proceedings.
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| Free Research Field |
移植免疫
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