2017 Fiscal Year Final Research Report
Usefulness as the biomarker and effect in the iron metabolism of new splicing variant of hepcidin with liver cancer origin
| Project/Area Number |
15K19302
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ヘプシジン / スプライシングバリアント / バイオマーカー |
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| Outline of Final Research Achievements |
I built the system of measurement to detect hepcidin mRNA and splicing variant of hepcidin mRNA from serum exosome with Digital PCR.
Splicing variant of hepcidin mRNA was not detected in healthy person and liver cirrhosis patients without the past of the liver cancer, but it was detected in some liver cirrhosis patients with the past of the liver cancer and liver cancer patients. Splicing variant of hepcidin mRNA was not detected in pancreatic cancer, stomach cancer, and colon cancer patients. From these results, splicing variant of hepcidin mRNA was considered as new useful biomarker in the liver cancer.
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| Free Research Field |
血液学
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