2016 Fiscal Year Final Research Report
Analysis of niche forming factors (paneth cells) for colon cancer stem cells.
| Project/Area Number |
15K19309
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 大腸癌 / 幹細胞 |
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| Outline of Final Research Achievements |
Intestinal stem cells have the ability for both permanental self-renewal and differentiation into four types of intestinal epithelial cells. The intestinal stem cells play an important role in maintaining the intestinal homeostasis. However the presence of niche forming factors in colon cancer/adenoma stem cells was not clear. Here, we present that niche forming factors are also necessary for survival of colon cancer/adenoma stem cells and the possibility that EVs(Extracellular vesicles ) secreted from stem cells are involved in niche formation.
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| Free Research Field |
消化器内科
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