New stomach cancer model mouse using Cre expression H. pylori

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19315
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: The Institute for Adult Diseases Asahi Life Foundation
• Principal Investigator: Nobumi Suzuki 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) (30723746)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ピロリ菌 / 胃癌

Outline of Final Research Achievements

It is a well-known that H. pylori infection causes stomach cancer. On the other hand, H. pylori that can not infect C57BL / 6 mice, which is the source of genetically modified mice. This was a obstacle in mouse experiments. Recently it has been reported that PMSS 1 strain can infect. We confirmed that the PMSS 1 strain can infect B6 mice. Then we made the gastritis mice model by useing PMSS1 strain and we reported a paper that IL - 1 signal and SOX 9 are involved in intestinal metaplasia. Subsequently, PMSS 1 strain did not express Cre, but we make CagA of PMSS1 to be KO and we confirmed activation of stress MAPK was dependent on CagA.

Free Research Field

消化器内科