2017 Fiscal Year Final Research Report
Gastric carcinogenesis by autophagy impairment via Helicobacter pylori infection
| Project/Area Number |
15K19317
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | University of Toyama |
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Principal Investigator |
Nanjo Sohachi 富山大学, 大学院医学薬学研究部(医学), 助教 (70649285)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 胃がん / オートファジー / DNAメチル化 |
|---|
| Outline of Final Research Achievements |
This study showed the followings; 1) MAP1LC3A gene is regulated by DNA methylation of its promoter region, 2) The DNA methylation is induced by Helicobacter pylori infection in the stomach, 3) Knock-down of map1lc3a gene increases cell proliferation, migration and invasion. Therefore, Methylation silencing of MAP1LC3Av1 is induced by H. pylori infection, and may impair autophagy, facilitating gastric carcinogenesis.
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| Free Research Field |
慢性炎症発がん
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