Analysis of neurogenesis in the enteric nervous system with c-Kit mutant mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19321
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Nagoya University
• Principal Investigator: Tamada Hiromi 名古屋大学, 医学系研究科, 学振特別研究員(PD) (60712817)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 腸管神経系 / 神経再生 / c-Kit

Outline of Final Research Achievements

In this study, it was focused on that neurogenesis in the enteric nervous system was observed extremely in c-Kit mutant mice, compared to wildtype mice. After the ablation of myenteric plexus layer with benzalkonium chloride, the new neurons were appeared in the longitudinal muscle layer or the subserosal layer, where normally enteric neurons were not distributed. In addition, they were already differentiated into several neuronal subtypes and formed normal enteric ganglion 3 weeks after the ablation with benzalkonium chloride. The neurogenesis was also enhanced in wildtype mice with administration of imatinib, a c-Kit inhibitor, compared to wildtype mice without administration. From these results, it seems that c-Kit signaling regulates the neurogenesis inhibitory in adult gut.

Free Research Field

機能組織学