2016 Fiscal Year Final Research Report
The role of exosome in the crosstalk between cancer cells and fibroblast
Project/Area Number |
15K19326
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | 癌関連線維芽細胞 / 癌微小環境 |
Outline of Final Research Achievements |
The present study aimed to reveal the mechanism of the activation of fibrobaslts by cancer cells and the role of cancer-derived exosomes as the communication tool between cancer cells and fibroblasts. We studied the effect of co-existence of cancer cells and fibroblasts using cell lines and nude mice. It is indicated that p53 deficiency played a pivotal role in activation of fibroblast to produce VEGF via ROS production, resulting in tumor progression. We detected the microRNAs in the cancer-derived exosome which activated fibroblasts. These raise the possibility of the cancer-drived exosome as the novel therapeutic target or the useful biomarker.
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Free Research Field |
消化器癌
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