Development of therapy for liver cirrhosis : focused on energy metabolism of liver stellate cell

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Yamaguchi University
• Principal Investigator: IWAMOTO Takuya 山口大学, 医学(系)研究科(研究院), 助教 (80634716)
• Research Collaborator: FUJISAWA Koichi 山口大学, 大学院医学系研究科, 助教 (00448284)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肝硬変 / 肝星細胞

Outline of Final Research Achievements

Liver fibrosis is caused by damage of hepatocytes. Overexpression of extracellular matrix and reduction of degradation of extracellular matrix is related to fibrosis. We focused the basic research of energy metabolism of liver stellate cells and aimed to develop new therapy for improve liver fibrosis and liver cirrhosis. We have knockdown the expression of energy metabolism related genes and found that the AK gene isozyme is related to activation of liver stellate cells. We further investigated the gene expression analysis by IPA, and found some interesting pathway data.

Free Research Field

肝臓病学