The role of BAFF in progression of hepatocellular carcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19334
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: Koizumi Mitsuhito 愛媛大学, 医学部附属病院, 講師(病院教員) (40748307)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肝細胞癌 / ANP32B / BAFF

Outline of Final Research Achievements

Originally we aimed to identify the role of B cell activation factor belonging to the tumor necrosis factor family (BAFF) and its physiological significance in hepatocellular carcinoma (HCC). Using BAFF expression attenuated liver cancer cell lines, we failed to show significant features that may explain physiological alteration in HCC. During our above mentioned research, we encountered to a protein, Acidic Nuclear Phosphoprotein 32 Family Member B (ANP32B), which may contribute to the pathogenesis of HCC. Therefore, we investigated the role of ANP32B in HCC. ANP32B was expressed in human HCC tissue and low levels of ANP32B were correlated with poor prognosis. Down-regulation of ANP32B plays a role in the suppression of apoptosis and contributes to the progression of cancer.

Free Research Field

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