2016 Fiscal Year Final Research Report
Elucidation of the role of microRNA-27b for the development of NASH
| Project/Area Number |
15K19341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
IMAJO Kento 横浜市立大学, 附属病院, 助教 (30600192)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 非アルコール性脂肪肝炎 |
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| Outline of Final Research Achievements |
In this study, we have clarified that hepatic inflammation induced by hyper responsivity to endotoxin in fatty liver causes lipid excretion and metabolic disturbance by elevating microRNA - 27b (mir-27b), resulting in lipid metabolism disorder and accumulation of free fatty acid (FFA) which causes the development of NASH.
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| Free Research Field |
Hepatology
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