2017 Fiscal Year Final Research Report
Investigation of mechanisms of inflammatory bowel disease caused by interaction of high-fat diet and LRRK2, a susceptibility gene of IBD
| Project/Area Number |
15K19347
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 炎症性腸疾患 |
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of IBD caused by the interaction of LRRK2, a risk gene for inflammatory bowel disease and high fat diet. In analysis of the expression profile of LRRK2 in the gastrointestinal tract revealed that LRRK2 was mainly localized in the mucosal lamina propria of thecolon and in the auerbach-plexus. Next, intestinal permeability was significantly lowered in the high-fat diet intake group and the LRRK2 knockout mice (LRRK2-KO). Furthermore, comparison of colitis by DSS and TNBS showed that the inflammation was abrogated in the high-fat diet group, on the other hand, DSS colitis was exacerbated in LRRK2-KO. From these results, it was suggested that LRRK2 is involved in intestinal innate immunity.
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| Free Research Field |
病態生化学
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