2017 Fiscal Year Final Research Report
Is congestion only the reason for splenomegaly in liver cirrhosis? -What are the splenic immunological effects on liver fibrosis development?-
| Project/Area Number |
15K19350
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 肝線維化 / 脾臓 / マクロファージ / 肝星細胞 / リポカイン２ / 腸内細菌 / Kupffer細胞 / 腸肝相関 |
|---|
| Outline of Final Research Achievements |
The splenic immunological effects on liver fibrosis development are unclear. Increased Lipocalin-2 (Lcn2), an anti-microbial protein, was detected on the spleen with fibrotic liver in mice. Lcn2 suppressed excessive Kupffer cells activation, that lead inhibiting hepatic stellate cells activation. Splenectomized mice showed enhanced liver fibrosis and inflammation accompanied by significantly decreased Lcn2 levels in portal vein (PV). Interestingly, gut sterilization blocked the effect of splenectomy on liver fibrosis development. Thus, the splenic Lcn2, that enter the liver through PV, might have an important role in regulating Kupffer cells activation which relates to gut-derived products in liver fibrosis development.
|
| Free Research Field |
消化器内科学
|
