The potential of hepatitis B vaccine: from the B-cell

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19352
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: National Center for Global Health and Medicine (2016-2017); Showa University (2015)
• Principal Investigator: Hiroyoshi Doi 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (70465102)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: B型肝炎ワクチン / 濾胞性T細胞 / IFNγ / B細胞 / 再接種 / 抗体価

Outline of Final Research Achievements

The rational of non- or low- responses to Hepatitis B (HB) vaccine is not well elucidated. We retrospectively analyzed our vaccination records and found acquiring higher titers of anti-HBs by initial vaccination is indispensable for long term maintenance. We also prospectively analyzed the immune responses to HB vaccine using PBMC and sera in first-time vaccinated students. Significant increase of circulating follicular helper T-cell (cTfh) and activated antibody secreting cells (ASC) were observed only in responders. Interestingly, strong association between peripheral IFN-g concentration before vaccination and acquired anti-HBs was observed. Accordingly, tailoring immunological condition, for instance by adding adjuvants or combination vaccine, can be a strategy to rescue non-responders or acquire higher titers of anti-HBs.

Free Research Field

消化器内科学