2016 Fiscal Year Final Research Report
Nardilysin regulates sinus automaticity through transcription of HCN.
| Project/Area Number |
15K19376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
OHNO Mikiko 京都大学, 医学研究科, 助教 (10583198)
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| Research Collaborator |
NISHI Eiichiro 滋賀医科大学, 薬理学講座, 教授 (30362528)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 洞房結節自動能 / 心不全 |
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| Outline of Final Research Achievements |
Nardilysin is a multi-functional protein, which regulates ectodomain shedding of membrane anchored protein in the cell surface and transcription in the nucleus. NRDc knockout mice show bradycardia because of poor expression of HCN channels in the heart. HCN is one of the critical regulator for sinus automaticity. We found that NRDc regulates mRNA and protein expression of HCN4.
Furthermore, since HCN4 inhibitor is useful for heart failure in humans, we analyzed the significance of NRDc in the heart failure using mouse TAC (transverse aortic constriction) model.
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| Free Research Field |
循環器内科
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