2016 Fiscal Year Final Research Report
Elucidation of the role of cardiac fibroblast-derived CNP in myocardial remodeling and its therapeutic significance
| Project/Area Number |
15K19377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
minami takeya 京都大学, 医学研究科, 客員研究員 (00647208)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 分子心臓病学 |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the role of C type natriuretic peptide(CNP) secreted from cardiac myofibroblast on cardiac remodeling and the molecular mechanism involved in it by using cardiac constituent cell specific CNP or GC-B knockout mice, and is to clarify the significance of CNP on prevention of cardiac hypertrophy and heart failure. In this study, cardiac hypertrophy due to pressure overload exacerbated in myofibroblast-specific CNP knockout mice compared with control mice. These data suggested that the myofibroblast-derived CNP plays a protective role in pathological myocardial remodeling.
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| Free Research Field |
循環器内科学
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