The physiological and statistical relationship of a development of heart failure of preserved ejection fraction and an arterial baroreflex dysfunction

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19386
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyushu University
• Principal Investigator: Sakamoto Kazuo 九州大学, 医学研究院, 共同研究員 (80722363)
• Research Collaborator: OGA Yasuhiro
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 動脈圧受容器反射 / 心不全 / 自律神経不全 / モデル化

Outline of Final Research Achievements

I clarified the relationship between left atrial pressure fluctuation due to volume intolerance and heart failure in freely moving arterial baroreceptor deficient animal and established a method to stratify the arterial baroreflex function by incorporating a physiological model and computer simulation of baroreflex system. Next, I collected and analyzed the data of blood pressure in humans, and validated the measured blood pressure and optimized the analytical model. Using the analytical model, I found that the elderly's baroreflex function has declined. Furthermore, to improve the simulation accuracy, the analytical model was optimized using heart failure animal models and then the accuracy was improved. The established analytical model of arterial baroreflex function in humans has enabled the quantitative evaluation of the reflex.

Free Research Field

循環器内科学