The inhibitory effect of ANP on sympathetic nervous activity via mineralocorticoid receptor

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19392
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Nara Medical University
• Principal Investigator: Nakagawa Hitoshi 奈良県立医科大学, 医学部附属病院, 研究員 (20533730)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ナトリウム利尿ペプチド / ミネラルコルチコイド受容体 / 交感神経

Outline of Final Research Achievements

We reported that natriuretic peptide prevented heart failure by inhibiting mineralocorticoid receptor (MR) activity via guanylyl cyclase-A (GC-A). In this study, we found that urinary catecholamine was increased in GC-A KO than wild type mice, indicating the enhanced sympathetic nervous activity. To investigate whether natriuretic peptide inhibits sympathetic nervous activity by inhibiting MR or not, we applied MR blocker to cerebral ventricle. However, urinary catecholamine was not suppressed in GC-A KO mice after intracerebral infusion of MR blocker. We conclude that the enhanced activity of sympathetic nervous system in GC-A KO mice may be independent of MR in the brain.

Free Research Field

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