2016 Fiscal Year Final Research Report
Intracellular analysis of M-CSF induced lymphangiogenesis stimulating factor VEGF-C,-D production
| Project/Area Number |
15K19408
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Tsukita Youko 東北大学, 大学院医学系研究科, 大学院生
Komatsu Riyo 東北大学, 大学院医学系研究科, 大学院生
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | リンパ管新生 / VEGF-C / VEGF-D / 横隔膜 / MCSF |
|---|
| Outline of Final Research Achievements |
The experimental plan was changed because the VEGF-C, -D production from the skeletal muscle cell line by the addition of MCSF which was the initial objective was not significantly observed. In our previous study, significant VEGF-C, -D production was also seen from the diaphragm by MCSF administration, experiments were conducted focusing on the lymphatic vessels of the diaphragm.The pleural blood vessels and lymphatic vessels are involved in pleural effusion. Therefore, we prepared a malignant pleurisy model and an inflammatory pleurisy model and analyzed lymphatic vessels. In both models, expansion of lymphatic vessel diameter was observed.And only in malignant pleurisy model,lymphatic vessel density was increased.We concluded that the increase in VEGF-C, -D production from the diaphragm by cancer and inflammation will bring about these changes.
|
| Free Research Field |
リンパ管新生
|
