New biomarkers for sarcoidosis by metabolomics analysis using plasma and urine from patients.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Muramatsu Soshi 東北大学, 医学系研究科, 大学院非常勤講師 (30732549)
• Research Collaborator: SAIGUSA DAISUKE 東北大学, 東北メディカル・メガバンク機構, 講師 (90545237) ; MURAKAMI KOJI 東北大学, 大学病院, 助教 ; GAMO SYUNICHI 東北大学, 大学病院, 医員 ; ARITAKE HIDEMI 東北大学, 医学系研究科, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メタボロミクス解析 / 新規バイオマーカー / フェノタイプ

Outline of Final Research Achievements

Sarcoidosis is a systemic disease of unknown cause that is characterized by the formation of immune non-caseating granulomas in various organs, mainly the lungs and the mediastinal/bilateral hilar lymph nodes. To find candidates for disease biomarkers of sarcoidosis, we collected over 100 plasma and urine from patients with active and inactive sarcoidosis, and analyzed the correlation of difference between analytes by HCA analysis using over 150 metabolites detected by GC-MS/MS assays.In the comparison between active and inactive sarcoidosis using serum, 9 metabolites were found to be significantly dysregulated in active sarcoidosis, when a significance level of p<0.05 was applied. In case of the comparison using urine, significance was accepted as p<0.15,

Free Research Field

呼吸器内科