2016 Fiscal Year Final Research Report
The role of proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells and T cells in a murine asthma model
| Project/Area Number |
15K19412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
Saito Haruka 群馬大学, 医学部附属病院, 医員 (80447268)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | アレルギー |
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| Outline of Final Research Achievements |
Ovarian cancer G protein-coupled receptor 1 (OGR1) stimulation by extracellular protons causes the activation of G proteins and subsequent cellular functions. Expression and the role of OGR1 at the cell level were unknown. We confirmed OGR1 mRNA expression assessed by real-time TaqMan PCR in peribronchial lymph node, CD４+Tcell and CD8+Tcell from splenocyte of WT mice. OGR1 developed in the peribronchial lymph node which I gathered from house dust induced bronchial asthma model. Furthermore, OGR1 developed in isolated CD4+T cell, CD8+T cell by magnetic beads from a splenocyte.
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| Free Research Field |
呼吸器内科
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