2016 Fiscal Year Final Research Report
Analysis of the functional roles of TAZ in lung cancer and lung fibrosis with a focus on lung mesenchyme
| Project/Area Number |
15K19414
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | TAZ / Hippo pathway / 肺線維症 |
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| Outline of Final Research Achievements |
TAZ, a key component of the Hippo pathway, regulates a variety of biological processes including control of organ size and cancer progression. In this study, we explored the roles of TAZ in the pathogenesis of idiopathic pulmonary fibrosis (IPF) through histological analyses of human lung tissues and cell culture experiments. TAZ was highly expressed in the fibroblastic foci of lungs from patients with IPF. TAZ controlled myofibroblast marker expression, proliferation, migration, and matrix contraction in cultured lung fibroblasts. Gene expression profiling revealed TAZ-mediated regulation of connective tissue growth factor and type I collagen. These findings suggest that TAZ is involved in the pathogenesis of IPF through multifaceted effects on lung fibroblasts.
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| Free Research Field |
呼吸器内科学
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