Exploring the mechanism of obesity related abnormal adipokine - induced hypertension and renal impairment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19443
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Kawarazaki Wakako 東京大学, 先端科学技術研究センター, 特任助教 (50424594)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肥満 / 高血圧 / 食塩感受性 / Klotho / 腎尿細管 / ナトリウム輸送体

Outline of Final Research Achievements

The prevalence of obesity has increased markedly and it　is deeply associated with cardiovascular, metabolic, and renal diseases. Some clinical studies have suggested that the salt-sensitivity of blood pressure is enhanced in obese people, and it may be the reason why obese people are prone to develop hypertension, but the mechanism is still unknown.
We hypothesized that abnormality of adipokine specific to obesity may induce the aberrant activation of renal tubular sodium transporters and cause salt-sensitive hypertension. In the comparison of obese and lean salt-sensitive model rats, we demonstrated the same dose of sodium was more likely to develop hypertension and renal impairment in obese rats, and they accompanied abnormality of the renal sodium transporter. Now, we are examining how the abnormality of the adipokines specific to the obesity cause enhanced salt-sensitivity in obese subjects.

Free Research Field

腎臓・高血圧