2016 Fiscal Year Final Research Report
The role of throid hormone receptor relating to ER stress response in the kidney.
| Project/Area Number |
15K19451
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Research Collaborator |
FURUYA Fumihiko (90456450)
KITAMURA Kenichiro (10304990)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ERストレス / 甲状腺ホルモン受容体 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
There are 13 million chronic kidney disease (CKD) patients and ten thousand of them are required to start dialysis treatment every year in Japan. There is a need to develop curative treatments of CKD. This study was made to reveal the effects of endogenous thyroid hormone receptor (TR) α on the progression of CKD. Therefore we focused on the endoplasmic reticulum stress pathway in the kidney of TRαKO mice with unilateral ureteral obstruction (UUO)-induced kidney injury model for CKD.
Our experimental results suggested that endogenous thyroid hormone receptor α has inhibitory effects on progression of kidney fibrosis.
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| Free Research Field |
腎臓内科
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