Clarification of multi-organ communication controlling with phosphate and vitamin D metabolism.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19455
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: KANEKO Ichiro 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (40389515)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リン / ビタミンD

Outline of Final Research Achievements

Bone-mineral metabolic abnormalities associated with Chronic Kidney Disease (CKD) are "multiple organ diseases" caused by failure of phosphate metabolism. In this study, we analyzed the mechanism of abnormal mineral metabolism across multiple organs and its therapeutic effects. In CKD-induced vitamin D receptor (VDR)-deficient mice, suppression of blood urea nitrogen and phosphorus elevation was observed, suggesting that the inhibition of VDR is effective for renal protection. Furthermore, the importance of tissue selective VDR action and the therapeutic effects by low phosphate diet or vitamin D administration are evaluated.
Also, we comprehensively detected metabolic (biological) products using metabolome analyzers, and obtained enormous data. Based on these results, we are attempting to identify early diagnostic markers for CKD-Mineral Bone Disorder and predictive markers for multiple organ complications.

Free Research Field

腎臓分子栄養学