2017 Fiscal Year Final Research Report
Synthetic retinoid Am80, an inhibitor of Kruppel-like factor 5 suppresses the progression of peritoneal fibrosis in a mouse experimental model
| Project/Area Number |
15K19457
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
MUTA Kumiko 長崎大学, 病院(医学系), 助教 (10728546)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 腹膜透析 / Kruppel-like factor 5 / Am80 |
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| Outline of Final Research Achievements |
Kruppel-like transcription factor 5 (KLF5) is a transcription factor regulating biochemical process of cell proliferation, angiogenesis and differentiation. It has been recently reported that Am80, a synthetic retinoic acid receptorα specific agonist, inhibits the expression of KLF5. In the present study, we examined the expression of KLF5 in fibrotic peritoneum induced by chlorhexidine gluconate in mouse, and evaluated that Am80, an inhibitor of KLF5, can reduce peritoneal fibrosis.
Our results indicate the involvement of KLF5 in the progression of experimental peritoneal fibrosis and suggest that Am80 may be a potentially useful for the prevention of peritoneal fibrosis through inhibition of KLF5 expression.
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| Free Research Field |
腎臓内科
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