2016 Fiscal Year Final Research Report
The role of chronic inflammation on renal recovery after AKI
| Project/Area Number |
15K19459
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
Hayata Manabu 熊本大学, 医学部附属病院, 助教 (30646120)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 急性腎障害 / 慢性腎臓病 / 慢性炎症 |
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| Outline of Final Research Achievements |
It is unclear how the underlying chronic inflammation in lifestyle-related diseases affects on the process of transition from AKI to CKD. In the chronic phase after IRI to the unilateral kidney of B6 mouse, the injured side kidney becomes atrophic. Although similar experiments were conducted using DIO and db/db mice as MetS models, a large amount of subcutaneous fats made it difficult to stabilize the IRI technical procedure enough to evaluate the chronic renal injury. Now, the pathway gene analysis by PCR array is in progress using chronic AKI tissues.
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| Free Research Field |
腎臓内科
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