2016 Fiscal Year Final Research Report
Chronic kidney disease (CKD) and Cognitive impairment: Possible mechanisms of Cerebro-renal interaction
| Project/Area Number |
15K19461
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Tohoku University (2016)
Fukushima Medical University (2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 脳腎連関障害 / 認知機能障害 / 慢性腎臓病 |
|---|
| Outline of Final Research Achievements |
Recent study demonstrated that one third of CKD patients developed cognitive impairment, which is also revealed as an independent risk factor for survival. However, concise mechanism of cerebro-renal interaction has not been clarified. We aimed to examine the pathophysiology of cognitive dysfunction accompanied by CKD. The groups did not differ in cognitive functioning during the course of study. Histologically, increased numbers of pyknotic neuronal cells were observed in the hippocampus in a half of CKD rats, but this change was not observed in the control. CKD rats accompanied with hippocampus damage demonstrated the tendency of poor learning process, higher activity, oxidative stress makers, systolic blood pressure, pulse pressure, urinary angiotensinogen and lower antioxidant markers. Multiple factors are speculated as the pathophysiology of cognitive impairment accompanied by CKD.
|
| Free Research Field |
腎臓内科学
|
