2016 Fiscal Year Final Research Report
The role of glycosylation of renal mineralocorticoid receptor in hypertension and renal dysfunction.
Project/Area Number |
15K19464
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
|
Research Institution | Keio University |
Principal Investigator |
TAKEDA Ayano 慶應義塾大学, 保健管理センター(日吉), 講師 (90468497)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | ミネラルコルチコイド受容体(MR) / 糖鎖修飾 / OGT(O-GluNAc転移酵素) / 糖尿病 |
Outline of Final Research Achievements |
We established podocyte-specific and renal tubule-secific O-GlcNAc transferase (OGT) transgenic mouse models and analyzed their phenotypes to elucidate the effect of glycosylation of mineralocorticoid receptor (MR) in hypertension and renal dysfunction. MR activity examined in kidney tissues was enhanced in renal tubule-specific OGT transgenic mice, which suggested that the glycosylation of MR could be involved in the underlying mechanism of “MR-associated hypertension” in diabetes.
|
Free Research Field |
腎臓内分泌
|